RIO North America and RIO Europe: waist circumference (cm)
Difference
between groups, mean (SEM)
LOCF
20mg vs Pbo-4.2 (0.5) (p<0.001)
-4.5cm
-8.5cm
Baseline mean (SD)108.4 (14.1)
-10
-8
-6
-4
-2
0
0
4
8
12
16
20
24
28
32
36
40
44
48
52
LOCF
Difference
between groups, mean (SEM)
LOCF20mg
vs Pbo-3.6 (0.3)
(p<0.001)
-3.9cm
-8.2cm
Baseline mean (SD)105.8 (15.3)
-10
-8
-6
-4
-2
0
0
4
8
12
16
20
24
28
32
36
40
44
48
52
LOCF
RIO North America
RIO Europe
Pi-Sunyer
FX et al, 2006;Van Gaal L et al, 2005
ITT population
Reductions in
waist circumference observed cases by visit and LOCF
The results for
waist circumference paralleled the results for weight in RIO North America
and RIO Europe as shown here. Results for the two other studies, though not
shown,were similar.