RIO Lipids
: HDL-C and triglycerides (
% change
)
Baseline
mean (SD)
1.10 (0.24) mmol/L
Difference between groups, mean (SEM)
LOCF
20mg vs
Pbo
8.0 (1.5) (p<0.001)
Difference between groups, mean (SEM)
LOCF
20mg vs
Pbo
-12.4 (3.2) (p<0.001)
Baseline
mean (SD)
2.09 (1.23) mmol/L
Despr
é
s JP et al, 2005
11.8
23.4
-5
0
5
10
15
20
25
0
4
8
12
16
20
24
28
32
36
40
44
48
52
LOCF
-15.7
-3.6
-25
-20
-15
-10
-5
0
5
0
4
8
12
16
20
24
28
32
36
40
44
48
52
LOCF
RIO Lipids: HDL-C and triglycerides change
In RIO Lipids in patients treated for 1 year, rimonabant 20 mg significantly increased HDL by more than 23%, an effect of 8% over placebo and decreased triglycerides by 16%, a net 12% versus the effects seen in the placebo group (p<0.001 for both).