RIO Europe: HDL-C and triglycerides (% change)
after 2 years
Difference
between groups, mean (SEM)
LOCF20mg vs Pbo 10.0 (1.5)
(p<0.001)
Difference
between groups, mean (SEM)
LOC 20mg vs Pbo -14.0 (3.1) (p<0.001)
Van Gaal
L et al, 2005, Van Gaal L et al,ACC 2005
28.2%
Baseline
mmol/L mean (SD)1.27 (0.33)
Baseline
mmol/Lmean (SD)1.45 (0.88)
17.4%
0
5
10
15
20
25
30
0
8
16
24
32
40
48
56
64
72
80
88
96
104
LOCF
4.2%
-9.0%
-15
-10
-5
0
5
10
15
0
8
16
24
32
40
48
56
64
72
80
88
96
104
LOCF
RIO Europe: HDL-C
and triglyceride changes after 2 years
These improvements
in lipids are durable. The favourable effects on HDL-C and triglycerides were
maintained over time for 2 years as shown in the RIO Europe trial. This was
also true in RIO North America for patients who were on the same treatment
groups for 2 years.