-0.4
-0.2
0.1
-0.9
-0.2
-1.7
-0.7
-1.9
+0.2
p=0.655
78.1
77.7
79.7
79.4
78.2
78.2
78.8
79.0
-1.0
p=0.096
-1.6
p=0.011
-1.2
p=0.060
Effects on supine
diastolic BP
across the
4 RIO studies
(mean change from baseline)
Placebo
Rimonabant 20 mg
Baseline DBP
Pi-Sunyer FX et al, 2006; Despr
é
s JP et al, 2005; Van Gaal L et al, 2005
-2.5
-2
-1.5
-1
-0.5
0
0.5
1
1.5
2
All RIO studies: supine diastolic blood pressure placebo-subtracted difference
Effects on supine diastolic blood pressure across the four RIO studies, mean change from baseline