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RIO Diabetes:
lower weight, HbA1c and FPG
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RIO Diabetes studied
patients with A1c between 6.5 and 10%. At screening over 70% of
patients had an A1c over 7%.
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The lifestyle
changes prescribed by the dieticians induced a transient decease in A1c
by 0.2% during the run-in period that preceded baseline. Therefore a
relatively low mean A1C of 7.3% was observed at baseline.
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In terms of fasting
glucose, the effects of lifestyle changes were transient in the placebo
group, whereas there was a continuous decrease in the 20 mg group. This
improved glucose control is confirmed by a reduction of almost 1 mM of the
fasting glucose.
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In terms of weight,
when rimonabant was added, weight decreased with both background therapies,
metformin and sulphonylurea. As most oral antidiabetic agents are known to be
associated with weight gain and given the fact that weight control is an
essential part of the management of patients with type 2 diabetes, this is a
remarkable finding.
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