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CB1
receptor expression is widespread centrally and peripherally in brain,
adipose tissue, muscle, liver and the gastrointestinal tract (Di
Marzo V, 2001; Ravinet Trillou C, 2003; Cota D, 2003; Pagotto U, 2005; Van
Gaal L, 2005; Liu Y 2005; Osei-Hyiaman D 2005; Massa F, 2005 ).
The ECS acts centrally in the hypothalamus to influence orexigenic drive and
has been shown to interact with other hypothalamic neuropeptides known to be
involved in the regulation of energy balance and lipid and glucose metabolism
(Di Marzo V, 2001; Cota D, 2003).
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